>In every city and town different parts have different zoning

I'm fairly certain that in Maine there is case law wherein “spot zoning” is the singling out of one lot or a small area for different treatment under the zoning code even though the lot receiving different treatment is indistinguishable from surrounding parcels with respect to physical characteristics and potential uses.

As to MA, spot zoning is, as the link states, unlawful. If it was allowed to occur, it was only because no one challenged it. Judges rarely allow it for small, house-size properties. https://www.phillips-angley.com/blog/2021/05/spot-zoning-what-you-should-know/