From Garrett Reisman:

Yes, for long-duration spaceflight in a microgravity environment, artificial gravity offers a lot of advantages to alleviate or eliminate various physiological issues associated with adaptation to microgravity. Also, there would be many practical advantages too, including:

• Locomotion (walking) becomes more natural

• Fluids separate (air-liquid) and there is natural convection

• Terrestrial tools and processes are easier to adapt

• Items remain where they are placed

But using rotation to create artificial gravity would require a combination of rotation rate and diameter that would present significant engineering challenges.

Consider this table which gives combinations of speeds and rotation rates to create an artificial gravity level equivalent to ours on Earth:

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So either your spacecraft has to be huge or spin very fast. And spinning fast will cause you to run into problems associated with the limits of human physiological tolerance.

So it's not easy!