Here I am, with a list of developments I've kept hopeful track of, but ok.

Reasons for hope:

• John Goodenough's battery

• XNRGI's battery

• Lyten lithum sulfur batteries

• solar shingles

• SpaceX

• magnetic reconnection space drive (Fatima Ebrahimi) (2021) hopes to have a first prototype soon

• Mach Effect

• "augmented reality", HoloLens

• hot fusion companies (including Apollo Fusion)

• Quaise Energy geothermal power

• detonation engine for rockets

• NMN

• Gaianneschi fatty acid drug delivery (2019, no news since)

• DpC

• TREM

• ISRIB: small molecue cognitive enhanc

• PAMPS hydrogel for cartilege = Bolt Biotheraputics's ISAC anti-cancer therapy

• Alkahest young blood plasma for brain healing

• αKLOTHO and TGFβR2 treatment for osteoarthritis

• NaNots (NaNotics) - subtractive nanoparticles

• Senisca - correcting dysregulation of RNA processing (2021)

• retrolytics (2020, Andrew Gudkov)

• GlyNAC (Rajagopal Sekhar)

• LyGenesis (2022, starting first human trial)

• Lomecel-B

• senolytics

• David Sinclair (Harvard)'s anti-aging pill (SOCOM trial)

• elements from young blood

• hypothalamus regeneration

• trodusquemine (aka MSI-1436) = Novo Biosciences is struggling for funding

• Underdog Pharmaceuticals - now Cyclarity - clearing arteriosclerosis

• LNP mRNA to restore heart function by reprogramming T cells to remove fibrotic cells (Jan 2022)

• carbon nanotubes for atherosclerosis (2020)

• Mitrix Bio - harvesting healthy mitochondria from a bioreactor for transplant

• Satellite Bio

• mRNA delivery of Stemin and YAP5SA to repair hearts (Robert Schwartz) 2022

• anti-CD47 and other immune system activating treatments

• iNKT cell reinvigoration via galactosylceramide (2018)

• SeNBD (May 2021)

• MuTaTo (2019)

• metarrestin - preventing metastasis - now in a phase I clinical trial (2021)

• Hadiyah-Nicole Green (nano-particles with laser therapy) Ora Lee Smith Center (2020) trying to crowdfund there was another group that reported results with this... from Wales maybe?

• PRL3-zumab humanized antibody binds PRL3 thereby inhibiting tumors, phase II clinical trial (2021)

• GP532 a TLR5 agonist, Andrei Gudkov (2021)

• MR1 (Enara Bio) (universal anti-cancer T cell therapy) (2020)

• T cells: BAFT upregulation

• allogenic iNKT (invariant natural killer) cells, Yang Lab (2021)

• nanoparticles from maize (2022)

• aspirin could cut risk of death in cancer

• ELANE/PPE (2021, Becker, Onchilles Pharma)

• Clinically translatable cytokine delivery platform for eradication of intraperitoneal tumors (2022, Nash and Veish) (drug factory beads)

• albumin nanoparticle (2022, Duxin Sun)

• dostarlimab (PD-1 inhibitor, anti-cancer) (2022)

• cancer-killing “drug factory” implants ( Veiseh, Avenge Bio) 2022 -LIfT BioSciences N-LIfT

Revisit later:

• plasminogen supplement? (sea squirt)

Dud list:

• BLP
• MKC8866