I'm also reading the bobiverse right now. A way to do this and minimize trauma for the first generation, would be to digitize several people, have them build and populate a small community of androids, and only then start creating the kids. The embryos could even be descendants of the uploaded people. If you can store the data densely enough, and can build a small enough printer that can build larger things, the spaceship itself could be quite tiny. The largest issue would then probably be slowing down at the end (you can get it going with a laser). And of course, longevity of the ship.