Obviously just blind speculation…

Previously unimaginable housing insecurity and economic crises spurred by overpopulation and a lack of sufficient housing on a massive scale, which could stem from a population “rebound” in the wake of some sort of mass casualty event (coastal/inland flooding, plague, blight, nuclear, etc).

More novel viruses/bacteria, whether unearthed out of permafrost, extraterrestrial super-germ or AI-produced bio-weapon.

Increased ease of travel — hypersonic (or the 2322 equivalent) commercial air travel, high-speed rail — due to technological advancement and a reliance on cheap renewable fuel sources… but less cordiality between nations, warring and global unrest make experiencing cultures in other parts of the world unsafe and prohibitively expensive. Capitalism maybe falls out of favor among (most) western nations.

Unless mankind has some sort of impromptu moment of clarity and opts to recalibrate their default settings, the poor will continue to be the apparatus by which the elite/mega-rich hold onto their power and influence. Life will become much harder for many, many more people.