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That would be life changing for so many people. Innovations like this offer hope for the future in the way few other things can. I'm crossing my fingers this translates easily to Humans and is widely rolled out (I would imagine if it isn't rolled out widely we'll just get mutations developing that overcome the new immune capabilities).

I wonder if something similar could be developed for kidney stones and associated issues.

This is the upgraded version of drinking cranberry juice (which really does work in a percentage of cases as it can block receptors on urinary tract epithelial cells to which some types of E.coli can attach)

That said, from my day to day laboratory work, of the 80-100 samples a day on which we do sensitivity testing, only about 60% will be E.coli.

Would this lead to extra inflammation in the GI tract?

I'm always excited for new treatments for recurring UTIs, especially for catheter users.

Is this a tablet that needs to be taken daily? Does it maintain effectiveness for a longer period of time? Because if we're talking about daily medications that are preventatives for UTIs, we do have an older medication known as methenamine hippurate which is quite effective at preventing UTIs, and must be taken either once or twice daily with vitamin C, as a preventative.

I wonder what the difference is here in longevity as it is referred to as a "vaccine" tablet.

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Nice! Kind of a specific anxiety of mine, have been ok in adulthood, but as a young child I'd get UTIs so frequently doctors were worried antibiotics would stop working on them. How awesome it'd be to not have as much anxiety about the issue returning!

I wouldn’t think so but it’s a valid concern. Your immune system is already primed to attack any of the gut bacteria should they escape (and in fact they do regularly escape and are killed constantly). Also the interior of the gut is somewhat of an immunologically protected zone , I think of it as outside the body.

Kidney stones are not caused by bacteria so I don’t think a vaccine could prevent them. Interesting idea.

Since they are calling it a vaccine, I'd assume it isnt a daily medication, but that is just a guess.

In a separate human trials mentioned in the article the subjects had to spray something in their mouth daily for several months so I’d say possibly yes the pills might daily.

am I the only one that came to the comments to make sure the tablet went in the mouth?

Some of them are, actually—proteus mirabilis can cause struvite stones (staghorn calculi)

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This would truly be life changing for me. Even when you take all the precautions, some people are super prone to getting UTIs.

I took my cat with recurring UTIs (neurological issues) to a teaching vet hospital and they prescribed methenamine hippurate. They were pretty convinced it would help, but it gave her awful GI symptoms. I'd love a non antibiotic preventative for her even if it's daily, that doesn't cause those issues. It was too much, so I had to take her off of it. I'm not sure if people get those side effects but I hope not (extreme nausea/inappetance and really bad diarhhea).

This would be amazing for my mom. She has an extremely weak immune system and so gets UTIs frequently. But also since she's been on antibiotics so much, the majority of them no longer work for her and she's really afraid eventually none will, and a normal infection will kill her.

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Especially when you are older. I had an elderly relative with UTI and she basically went off her rocker for a couple weeks. This would be a huge improvement for old people.

great. having to get a needle stuck in the body is a underrated barrier to vaccine adoptation. polio was eradicated in most of the world so easily partiailly coz the solution was so easy and welcomed by children.... a sugar ball, or two at different times. way easier than needle.