The FLASH studies have shown the lower side effects by using a single pulse, so the idea when putting this into clinical practice would be a single shot. Obviously no fractionation, as this isn't relying on the 5 R's. It's relying on a transient radiation-induced hypoxia that affects tumor cells more as they're already hypoxic.

For clinical treatment they would be looking at multiple treatment head gantries so the tumor could be shot from multiple angles at once in a single pulse so that you get the benefit of the FLASH effect that this treatment relies on.