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the_lazykins t1_iu2xmqq wrote

Reply to comment by powabiatch in Major breakthrough in cancer research: Papers reveal 'dark matter' that contributes to disease's growth by Ezekiel_W

Hi, would you mind explaining an example of a non-genomic tx in this case, even if it’s something hypothetical? Or is that not what you meant?

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powabiatch t1_iu30406 wrote

While there are drugs that target epigenetic regulators (e.g. Ezh2 inhibitors), it’s not clear yet how the new data would take advantage of them (if they can at all). While some of these drugs have shown promise, all of them have some drawbacks because they affect so many genes, often leading to unwanted toxicities. But hopefully this type of new data may help refine when to use which epigenetic drugs in which combinations.

Even so, epigenetic drugs may not always be the best answer to epigenetic dysregulation in cancer cells - remains to be seen though.

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the_lazykins t1_iu30hhn wrote

Oh got it. Thank you, that gives me something to read up on tonight.

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